Bio Clinical study for Transthyretin and Other Parameter in serum of Patients with Asthma
DOI:
https://doi.org/10.65591/312y4t25Keywords:
Asthma, Transthyretin, Thyroid Hormones, Body Mass Index, Albumin, CholesterolAbstract
Asthma is one of the most common chronic diseases affecting both children and adults. Mortality rates vary based on factors such as stage of diagnosis, treatment options, and patient health. However, treatments in advanced stages often yield limited results, underscoring the importance of early detection to improve outcomes. In this study, we evaluated transthyretin levels as a potential biomarker for Asthma, along with general markers such as albumin, cholesterol, total protein, high-density lipoprotein (HDL), triglycerides, thyroid-stimulating hormone (TSH), triiodothyronine (T3), and tetraiodothyronine (T4) in both asthma patients and a control group. We included 60 asthma patients and 60 controls. Data on age and body mass index (BMI) were collected from all participants. Comparisons of biomarkers were made across genders and age groups. Significant changes in T3, T4 and TSH levels were observed in asthma patients compared to the control group. Thyroid-Stimulating Hormone (TSH) levels were higher in asthma patients, while triiodothyronine and tetraiodothyronine levels were lower and showed a positive correlation with triiodothyronine and thyroid-stimulating hormone (TSH) levels. ROC analysis revealed that TSH, cholesterol, high-density lipoprotein (HDL), and triglycerides were strong predictors of asthma diagnosis. Our results suggest that TSH, T3, and T4 can serve as reliable biomarkers for asthma. Early detection using these biomarkers can improve treatment outcomes and reduce mortality rates. Further research is needed to validate these findings and explore their potential in clinical settings. Incorporating TSH, T3, and T4 into routine screenings could enhance diagnostic accuracy and patient prognosis. While the study results indicated an association between cholesterol levels and the risk of developing or worsening asthma, as well as between triglycerides (TG), a positive relationship was also observed between triglycerides (TG), total cholesterol (TC), and asthma. Our study also represents a positive interaction between high-density lipoprotein (HDL) cholesterol levels and the prevalence of asthma, which could be biomarkers for disease diagnosis.
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